Publications

Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase. Shi, X., Botting, C.H., Li, P., Niglas, M., Brennan, B., Shirran, S.L., Szemiel, A.M., Elliott, R.M., (Jul2016) PNAS, 113(31)

Pironetin reacts covalently with cysteine-316 of a-tubulin to destabilize microtubule, Yang, J., Wang,Y., Wang, T., Jiang, J. Botting, C.H., Liu, H., Chen, Q., Yang, J, Naismith, J.H., Zhu, X., Chen, L., Nat.Commun., (Jun 2016) 30;7:12103.

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.Paquet, N., Adams, M.N., Ashton, N.W., Touma, C., Gamsjaeger, R., Cubeddu, L., Leong, V., Beard, S., Bolderson, E., Botting, C.H., O’Byrne, K.J., Richard, D.J. Nat. Sci Rep. (Jun2016) 8,6, 27446

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Fuller, H.R., Mandefro, B., Shirran, S.L., Gross, A.R., Kaus, A.S., Botting, C.H., Morris, G.E., Sareen, D., Front Cell Neurosci. (2016), 9, 506.

Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion. Gunnigle, E., Nielsen, J.L., Fuszard, M., Botting, C.H., Sheahan, J., O’Flaherty, V., Abram, F., FEMS Microbiol Ecol. (2015), 91

An internal thioester in a pathogen surface protein mediates covalent host binding, Walden, M., Edwards, J.M., Dziewulska, A.M., Bergmann, R., Saalbach,  G., Kan, S.-Y., Miller, O.K., Weckener,  M., Jackson,  R.J., Shirran, S.L., Botting, C.H., Florence, G.J., Rohde, M., Banfield, M.J., Schwarz-Linek,  U., eLife, (2015), 4, 24

A secretagogin locus of the mammalian hypothalamus controls stress hormone release., Romanov, R.A., Alpár, A., Zhang, M.D., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S.L., Schnell, R., Dobolyi, A., Oláh, M., Spence, L., Mulder, J., Martens, H., Palkovits, M., Uhlen, M., Sitte, H.H., Botting, C.H., Wagner, L., Linnarsson, S., Hökfelt, T., Harkany, T., EMBO J. (2015) , 34, 36-54.

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis., Kasioulis, I., Syred, H.M., Tate, P., Finch, A., Shaw, J., Seawright, A., Fuszard, M., Botting, C.H., Shirran, S., Adams, I.R., Jackson, I.J., van Heyningen, V., Yeyati, P.L., Mol Biol Cell, (2014), 25, 1216-33

Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation., Kassaar, O., McMahon, S.A., Thompson, R., Botting, C.H., Naismith, J.H., Stewart, A.J., Blood, (2014), 123, 1948-55

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway., Tortoriello, G., Morris, C.V., Alpar, A., Fuzik, J., Shirran, S.L., Calvigioni, D., Keimpema, E., Botting, C.H., Reinecke, K., Herdegen, T., Courtney, M., Hurd, Y.L., Harkany, T., EMBO J, (2014), 33, 668-85.

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I., Babot, M., Labarbuta, P., Birch, A., Kee, S., Fuszard, M., Botting, C.H., Wittig, I., Heide, H., Galkin, A., Biochim Biophys Acta. (2014), 1837, 929-939.