Antiviral type III CRISPR signalling via conjugation of ATP and SAM Chi, H., Hoikkala, V. P., Gruschow, S., Graham, S., Shirran, S. L. & White, M., 26 Oct 2023, In: Nature. 622, 7984, p. 826-833 22 p.

AAV9-mediated SMN gene therapy rescues cardiac desmin but not Lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice Brown, S. J., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., Gillingwater, T. H., Yáñez-Muñoz, R. J., Schneider, B., Bowerman, M. & Fuller, H. R., 15 Oct 2023, In: Human Molecular Genetics. 32, 20, p. 2950-2965 16 p.

Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R. & Koehnke, J., 1 Apr 2023, In: Nature Chemistry. 15, 4, p. 560-568 9 p.

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O’Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.

Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles Kumar, P., Boyne, C., Brown, S. E., Qureshi, A., Thorpe, P. J., Synowsky, S. A., Shirran, S. L. & Powis, S. J., Jun 2022, In: Immunology. 166, 2, p. 249-264 15 p., 13471.

Investigation of the blood proteome in response to spinal cord injury in rodent models Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A. & Wright, K. T., 2 Oct 2021, In: Spinal cord. First Online, 6 p.

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R., Szodorai, E., Lubec, G., Shirran, S., Botting, C. H., Kasper, S., Guy, G. W., Gray, R., Di Marzo, V., Harkany, T. & Keimpema, E., 3 Dec 2020, In: JCI Insight. 5, 23, 20 p., e135418.

Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: implications for idiopathic Parkinson’s disease Gómez-Gálvez, Y., Fuller, H. R., Synowsky, S., Shirran, S. L. & Gates, M. A., (9 Apr 2020) Journal of Neuroscience Research. 

Substrate plasticity of a fungal peptide α-N-methyltransferase Song, H., Fahrig-Kamarauskaite, J., Matabaro, E., Kaspar, H., Shirran, S. L., Zach, C., Pace, A., Stefanov, B-A., Naismith, J. H. & Kunzler, M., (17 Jul 2020) : ACS Chemical Biology. 15, 7, p. 1901-1912 12 p.

Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy  Šoltić, D., Shorrock, H. K., Allardyce, H., Wilson, E. L., Holt, I., Synowsky, S. A., Shirran, S. L., Parson, S., Gillingwater, T. & Fuller, H.,(Aug 2019) : Human Molecular Genetics. 

Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach  Houeix, B., Synowsky, S. A., Cairns, MT., Kane, M., Kilcoyne, M. & Joshi, L., (11 Nov 2019) Integrative Biology. 11, 7, p. 315-329

Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy  Cinquina, V., Calvigioni, D., Farlik, M., Halbritter, F., Fife-Gernedl, V., Shirran, S. L., Fuszard, M. A., Botting, C. H., Poullet, P., Piscitelli, F., Máte, Z., Szabo, G., Yanagawa, Y., Kasper, S., Di Marzo, V., Mackie, K., McBain, C., Bock, C., Keimpema, E. & Harkany, T., (Nov 2019) Molecular Psychiatry. 15 p.

Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: a SWATH-MS study Arya, S., Wiatrek-Moumoulidis, D., Synowsky, S. A., Shirran, S. L., Botting, C. H., Powis, S. J. & Stewart, A. J., (13 Mar 2019) Scientific Reports. 9, 11 p., 4343.

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds Song, H., Van Der Velden, N. S., Shirran, S. L., Bleiziffer, P., Zach, C., Sieber, R., Imani, A. S., Krausbeck, F., Aebi, M., Freeman, M. F., Riniker, S., Künzler, M. & Naismith, J. H., (24 Aug 2018 Science Advances. 4, 8, 13 p., eaat2720.

Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates Ludewig, H, Czekster, CM, Oueis, E, Munday, ES, Arshad, M, Synowsky, SA, Bent, AF & Naismith, JH (Mar2018) ACS Chemical Biology, vol. 13, no. 3, pp. 801–811. DOI: 10.1021/acschembio.8b00050

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration. Arya, S. Emri, E., Synowsky, S.A., Shirran, S.L., Barzegar-Befroei, N., Peto, T., Botting, C.H., Lengyel, I. & Stewart, S.J.  Experimental Eye Research (Mar2018) vol. 172, pp. 21-29. DOI: 10.1016/j.exer.2018.03.023

The Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Mucular Atrophy pathology.  Thompson, L. W., Morrison, K. D., Shirran, S.L., Groen, E. J. N., Gillingwater, T. H., Botting, C.H. & Sleeman, J. E. Journal of Cell Science (Mar2018) vol 131, no8 DOI: 10.1242/jcs.211482, 10.1101/183640

The major histocompatibility complex class I immunopeptidome of extracellular vesicles.  Synowsky, S.A., Shirran, S.L., Cooke, F.G.M., Antoniou, A.N., Botting, C.H., Powis, S.J.,  Journal of Biological Chemistry (Oct2017) 292, p17084-17092

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases  Ashton, N.W., Paquet, N., Shirran, S.L.,  Bolderson, E.,  Kariawasam, R.,  Touma, C.,   Fallahbaghery, F., Gamsjaeger, R.,  Cubeddu, L.,   Botting, C.H., Pollock, P.M., O’Byrne, K.J.,  Richard, D.J.   DNA Repair, (June2017) 54 p30-39

Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase. Shi, X., Botting, C.H., Li, P., Niglas, M., Brennan, B., Shirran, S.L., Szemiel, A.M., Elliott, R.M., (Jul2016) PNAS, 113(31)

Pironetin reacts covalently with cysteine-316 of a-tubulin to destabilize microtubule, Yang, J., Wang,Y., Wang, T., Jiang, J. Botting, C.H., Liu, H., Chen, Q., Yang, J, Naismith, J.H., Zhu, X., Chen, L., Nat.Commun., (Jun 2016) 30;7:12103.

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.Paquet, N., Adams, M.N., Ashton, N.W., Touma, C., Gamsjaeger, R., Cubeddu, L., Leong, V., Beard, S., Bolderson, E., Botting, C.H., O’Byrne, K.J., Richard, D.J. Nat. Sci Rep. (Jun2016) 8,6, 27446

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Fuller, H.R., Mandefro, B., Shirran, S.L., Gross, A.R., Kaus, A.S., Botting, C.H., Morris, G.E., Sareen, D., Front Cell Neurosci. (2016), 9, 506.

Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion. Gunnigle, E., Nielsen, J.L., Fuszard, M., Botting, C.H., Sheahan, J., O’Flaherty, V., Abram, F., FEMS Microbiol Ecol. (2015), 91

An internal thioester in a pathogen surface protein mediates covalent host binding, Walden, M., Edwards, J.M., Dziewulska, A.M., Bergmann, R., Saalbach,  G., Kan, S.-Y., Miller, O.K., Weckener,  M., Jackson,  R.J., Shirran, S.L., Botting, C.H., Florence, G.J., Rohde, M., Banfield, M.J., Schwarz-Linek,  U., eLife, (2015), 4, 24

A secretagogin locus of the mammalian hypothalamus controls stress hormone release., Romanov, R.A., Alpár, A., Zhang, M.D., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S.L., Schnell, R., Dobolyi, A., Oláh, M., Spence, L., Mulder, J., Martens, H., Palkovits, M., Uhlen, M., Sitte, H.H., Botting, C.H., Wagner, L., Linnarsson, S., Hökfelt, T., Harkany, T., EMBO J. (2015) , 34, 36-54.

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis., Kasioulis, I., Syred, H.M., Tate, P., Finch, A., Shaw, J., Seawright, A., Fuszard, M., Botting, C.H., Shirran, S., Adams, I.R., Jackson, I.J., van Heyningen, V., Yeyati, P.L., Mol Biol Cell, (2014), 25, 1216-33

Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation., Kassaar, O., McMahon, S.A., Thompson, R., Botting, C.H., Naismith, J.H., Stewart, A.J., Blood, (2014), 123, 1948-55

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway., Tortoriello, G., Morris, C.V., Alpar, A., Fuzik, J., Shirran, S.L., Calvigioni, D., Keimpema, E., Botting, C.H., Reinecke, K., Herdegen, T., Courtney, M., Hurd, Y.L., Harkany, T., EMBO J, (2014), 33, 668-85.