Publications

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds Song, H., Van Der Velden, N. S., Shirran, S. L., Bleiziffer, P., Zach, C., Sieber, R., Imani, A. S., Krausbeck, F., Aebi, M., Freeman, M. F., Riniker, S., Künzler, M. & Naismith, J. H. 24 (Aug 2018)  Science Advances. 4, 8, 13 p., eaat2720

Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates Ludewig, H, Czekster, CM, Oueis, E, Munday, ES, Arshad, M, Synowsky, SA, Bent, AF & Naismith, JH (Mar2018) ACS Chemical Biology, vol. 13, no. 3, pp. 801–811. DOI: 10.1021/acschembio.8b00050

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration. Arya, S. Emri, E., Synowsky, S.A., Shirran, S.L., Barzegar-Befroei, N., Peto, T., Botting, C.H., Lengyel, I. & Stewart, S.J.  Experimental Eye Research (Mar2018) vol. 172, pp. 21-29. DOI: 10.1016/j.exer.2018.03.023

The Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Mucular Atrophy pathology.  Thompson, L. W., Morrison, K. D., Shirran, S.L., Groen, E. J. N., Gillingwater, T. H., Botting, C.H. & Sleeman, J. E. Journal of Cell Science (Mar2018) vol 131, no8 DOI: 10.1242/jcs.211482, 10.1101/183640

The major histocompatibility complex class I immunopeptidome of extracellular vesicles.  Synowsky, S.A., Shirran, S.L., Cooke, F.G.M., Antoniou, A.N., Botting, C.H., Powis, S.J.,  Journal of Biological Chemistry (Oct2017) 292, p17084-17092

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases  Ashton, N.W., Paquet, N., Shirran, S.L.,  Bolderson, E.,  Kariawasam, R.,  Touma, C.,   Fallahbaghery, F., Gamsjaeger, R.,  Cubeddu, L.,   Botting, C.H., Pollock, P.M., O’Byrne, K.J.,  Richard, D.J.   DNA Repair, (June2017) 54 p30-39

Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase. Shi, X., Botting, C.H., Li, P., Niglas, M., Brennan, B., Shirran, S.L., Szemiel, A.M., Elliott, R.M., (Jul2016) PNAS, 113(31)

Pironetin reacts covalently with cysteine-316 of a-tubulin to destabilize microtubule, Yang, J., Wang,Y., Wang, T., Jiang, J. Botting, C.H., Liu, H., Chen, Q., Yang, J, Naismith, J.H., Zhu, X., Chen, L., Nat.Commun., (Jun 2016) 30;7:12103.

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.Paquet, N., Adams, M.N., Ashton, N.W., Touma, C., Gamsjaeger, R., Cubeddu, L., Leong, V., Beard, S., Bolderson, E., Botting, C.H., O’Byrne, K.J., Richard, D.J. Nat. Sci Rep. (Jun2016) 8,6, 27446

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development. Fuller, H.R., Mandefro, B., Shirran, S.L., Gross, A.R., Kaus, A.S., Botting, C.H., Morris, G.E., Sareen, D., Front Cell Neurosci. (2016), 9, 506.

Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion. Gunnigle, E., Nielsen, J.L., Fuszard, M., Botting, C.H., Sheahan, J., O’Flaherty, V., Abram, F., FEMS Microbiol Ecol. (2015), 91

An internal thioester in a pathogen surface protein mediates covalent host binding, Walden, M., Edwards, J.M., Dziewulska, A.M., Bergmann, R., Saalbach,  G., Kan, S.-Y., Miller, O.K., Weckener,  M., Jackson,  R.J., Shirran, S.L., Botting, C.H., Florence, G.J., Rohde, M., Banfield, M.J., Schwarz-Linek,  U., eLife, (2015), 4, 24

A secretagogin locus of the mammalian hypothalamus controls stress hormone release., Romanov, R.A., Alpár, A., Zhang, M.D., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S.L., Schnell, R., Dobolyi, A., Oláh, M., Spence, L., Mulder, J., Martens, H., Palkovits, M., Uhlen, M., Sitte, H.H., Botting, C.H., Wagner, L., Linnarsson, S., Hökfelt, T., Harkany, T., EMBO J. (2015) , 34, 36-54.

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis., Kasioulis, I., Syred, H.M., Tate, P., Finch, A., Shaw, J., Seawright, A., Fuszard, M., Botting, C.H., Shirran, S., Adams, I.R., Jackson, I.J., van Heyningen, V., Yeyati, P.L., Mol Biol Cell, (2014), 25, 1216-33

Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation., Kassaar, O., McMahon, S.A., Thompson, R., Botting, C.H., Naismith, J.H., Stewart, A.J., Blood, (2014), 123, 1948-55

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway., Tortoriello, G., Morris, C.V., Alpar, A., Fuzik, J., Shirran, S.L., Calvigioni, D., Keimpema, E., Botting, C.H., Reinecke, K., Herdegen, T., Courtney, M., Hurd, Y.L., Harkany, T., EMBO J, (2014), 33, 668-85.

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I., Babot, M., Labarbuta, P., Birch, A., Kee, S., Fuszard, M., Botting, C.H., Wittig, I., Heide, H., Galkin, A., Biochim Biophys Acta. (2014), 1837, 929-939.